Effect of dengue virus infection on Fc-receptor functions of mouse macrophages

Fc-receptor-mediated attachment and ingestion of opsonized sheep erythrocytes (EA) by the macrophages of spleen and peritoneal cavity were studied during dengue virus type 2 (DV) infection of Swiss albino mice. Following intracerebral inoculation, virus antigen could be demonstrated by immunofluorescence in the splenic macrophages from day 4 and in peritoneal macrophages from day 5 post-infection, with a higher number of positive cells discernible on the 7th and 8th days. The virus could be isolated from spleen tissue from day 5. The total number of cells was markedly reduced from day 4 onwards both in the spleen and peritoneal cavity. A loss in the capacity to attach and ingest EA was noticed, the lowest values of attachment index (AI) and phagocytic index (PI) being reached on day 4. At later periods the AI values increased markedly but continued to be significantly less than those in uninfected control mice. The PI values continued to be lower throughout. The dichotomy between the Fc-mediated attachment and ingestion may be a mechanism for prevention of virus infection of macrophages

Majorization for Certain Classes of Analytic Multivalent Functions

In the present paper we investigate the majorization properties for certain classes of multivalent analytic functions defined by extended multiplier transformation. Moreover, we point out some new or known consequences of our main result

Kinetics of oxidation of phosphinic, phenylphosphinic and phosphorous acids by ethyl N-chlorocarbamate

784-788The oxidation of phosphinic, phenylphosphinic and phosphorous acids by ethyl -chlorocarbamate (ECC) in perchloric acid solution, results in the formation of corresponding phosphor s acids containing phosphorus in the higher oxidation state. The reaction is first order each in [ECC], and the oxyacid. Hydrogen ion dependence has the form: kobs=a +b [H+). Oxidation of deuteriated phosphinic and phosphorous acids show the presence of a substantial primary kinetic isotope effect. The reaction does not induce polymerization of acrylonitrile. Added ethyl carbamate, one of the products of the oxidation one reaction, has no effect on the reaction rate. Both ECC and ECCH+ have been postulated the reactive oxidizing species. It has been shown that the inactive tautomer of the phosphorus oxyacid RHP(O)OH, participates in the oxidation process. A rate-determining step involving transfer of a hydride ion from the P - H bond to the oxidant has been proposed

Effect of a fungal interferon inducer (6-MFA) on macrophage functions during dengue virus infection

Effect of 6-MFA, an interferon inducer of fungal origin having antiviral activity, was investigated on the functions of macrophages during dengue virus (DV) infection. It was observed that treatment of mice with 6-MFA abrogated the DV induced depression of attachment and phagocytosis of opsonized sheep erythrocytes by the peritoneal macrophages. This effect appears to be mediated by interferon. 6-MFA had no effect on the outcome of infection

BIOCHEMICAL ANALYSIS OF CASTOR CAKE

The present paper deals with study of variation of oil, protein, sugar and minerals present in castor cake. Besides it being used as an excellent source of organic fertilizers containing 6.5 % Nitrogen, 2.6 % Phosphorus pentaoxide and 1% Potash. Castor cake offers a good scope as an animal and poultry feed after detoxification

Epidemiology and Antifungal Susceptibility Patterns of Invasive Fungal Infections (IFIs) in India: A Prospective Observational Study

The epidemiology of invasive fungal infections (IFI) is ever evolving. The aim of the present study was to analyze the clinical, microbiological, susceptibility, and outcome data of IFI in Indian patients to identify determinants of infection and 30-day mortality. Proven and probable/putative IFI (defined according to modified European Organization for Research and Treatment of Cancer/Mycoses Study Group and AspICU criteria) from April 2017 to December 2018 were evaluated in a prospective observational study. All recruited patients were antifungal naïve (n = 3300). There were 253 episodes of IFI (7.6%) with 134 (52.9%) proven and 119 (47%) probable/putative infections. There were four major clusters of infection: invasive candidiasis (IC) (n = 53, 20.9%), cryptococcosis (n = 34, 13.4%), invasive aspergillosis (IA) (n = 103, 40.7%), and mucormycosis (n = 62, 24.5%). The significant risk factors were high particulate efficiency air (HEPA) room admission, ICU admission, prolonged exposure to corticosteroids, diabetes mellitus, chronic liver disease (CLD), acquired immunodeficiency syndrome (AIDS), coronary arterial disease (CAD), trauma, and multiorgan involvement (p 1). The all-cause 30-day mortality was 43.4% (n = 110). It varied by fungal group: 52.8% (28/53) in IC, 58.8% (20/34) in cryptococcosis, 39.8% (41/103) in IA, and 33.9% (21/62) in mucormycosis. HEPA room, ICU admission for IC; HEPA rooms, diabetes mellitus for cryptococcosis; hematological malignancies, chronic kidney disease (CKD), sepsis, galactomannan antigen index value ≥1 for IA and nodules; and ground glass opacities on radiology for mucormycosis were significant predictors of death (odds ratio >1). High minimum inhibitory concentration (MIC) values for azoles were observed in C. albicans, C. parapsilosis, C. glabrata, A. fumigatus, A. flavus, R. arrhizus, R. microsporus, and M. circinelloides. For echinocandin, high MIC values were seen in C. tropicalis, C. guillermondii, C. glabrata, and A. fumigatus. This study highlights the shift in epidemiology and also raises concern of high MICs to azoles among our isolates. It warrants regular surveillance, which can provide the local clinically correlated microbiological data to clinicians and which might aid in guiding patient treatment

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual